Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate.

Journal Article (Journal Article)

The water-reactive tissue adhesive 2-octyl cyanoacrylate (OCA) was microencapsulated in polyurethane shells and incorporated into Palacos R bone cement. The tensile and compressive properties of the composite material were investigated in accordance with commercial standards, and fracture toughness of the capsule-embedded bone cement was measured using the tapered double-cantilever beam geometry. Viability and proliferation of MG63 human osteosarcoma cells after culture with extracts from Palacos R bone cement, capsule-embedded Palacos R bone cement, and OCA were also analyzed. Incorporating up to 5 wt % capsules had little effect on the compressive and tensile properties of the composite, but greater than 5 wt % capsules reduced these values below commercial standards. Fracture toughness was increased by 13% through the incorporation of 3 wt % capsules and eventually decreased below the toughness of the capsule-free controls at capsule contents of 15 wt % and higher. The effect on cell proliferation and viability in response to extracts prepared from capsule-embedded and commercial bone cements were not significantly different from each other, whereas extracts from OCA were moderately toxic to cells. Overall, the addition of lower wt % of OCA-containing microcapsules to commercial bone cement was found to moderately increase static mechanical properties without increasing the toxicity of the material.

Full Text

Duke Authors

Cited Authors

  • Brochu, ABW; Evans, GA; Reichert, WM

Published Date

  • January 2014

Published In

Volume / Issue

  • 102 / 1

Start / End Page

  • 181 - 189

PubMed ID

  • 23913367

Pubmed Central ID

  • PMC4067161

Electronic International Standard Serial Number (EISSN)

  • 1552-4981

International Standard Serial Number (ISSN)

  • 1552-4973

Digital Object Identifier (DOI)

  • 10.1002/jbm.b.32994


  • eng