Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate.
Journal Article (Journal Article)
The water-reactive tissue adhesive 2-octyl cyanoacrylate (OCA) was microencapsulated in polyurethane shells and incorporated into Palacos R bone cement. The tensile and compressive properties of the composite material were investigated in accordance with commercial standards, and fracture toughness of the capsule-embedded bone cement was measured using the tapered double-cantilever beam geometry. Viability and proliferation of MG63 human osteosarcoma cells after culture with extracts from Palacos R bone cement, capsule-embedded Palacos R bone cement, and OCA were also analyzed. Incorporating up to 5 wt % capsules had little effect on the compressive and tensile properties of the composite, but greater than 5 wt % capsules reduced these values below commercial standards. Fracture toughness was increased by 13% through the incorporation of 3 wt % capsules and eventually decreased below the toughness of the capsule-free controls at capsule contents of 15 wt % and higher. The effect on cell proliferation and viability in response to extracts prepared from capsule-embedded and commercial bone cements were not significantly different from each other, whereas extracts from OCA were moderately toxic to cells. Overall, the addition of lower wt % of OCA-containing microcapsules to commercial bone cement was found to moderately increase static mechanical properties without increasing the toxicity of the material.
Full Text
Duke Authors
Cited Authors
- Brochu, ABW; Evans, GA; Reichert, WM
Published Date
- January 2014
Published In
Volume / Issue
- 102 / 1
Start / End Page
- 181 - 189
PubMed ID
- 23913367
Pubmed Central ID
- PMC4067161
Electronic International Standard Serial Number (EISSN)
- 1552-4981
International Standard Serial Number (ISSN)
- 1552-4973
Digital Object Identifier (DOI)
- 10.1002/jbm.b.32994
Language
- eng