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Brucellosis in low-income and middle-income countries.

Publication ,  Journal Article
Rubach, MP; Halliday, JEB; Cleaveland, S; Crump, JA
Published in: Curr Opin Infect Dis
October 2013

PURPOSE OF REVIEW: Human brucellosis is a neglected, underrecognized infection of widespread geographic distribution. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. This review describes new information regarding the epidemiology of brucellosis in the developing world and advances in diagnosis and treatment. RECENT FINDINGS: The highest recorded incidence of human brucellosis occurs in the Middle East and Central Asia. Fever etiology studies demonstrate brucellosis as a cause of undifferentiated febrile illness in the developing world. Brucellosis is a rare cause of fever among returning travelers, but is more common among travelers returning from the Middle East and North Africa. Sensitive and specific rapid diagnostic tests appropriate for resource-limited settings have been validated. Randomized controlled trials demonstrate that optimal treatment for human brucellosis consists of doxycycline and an aminoglycoside. Decreasing the burden of human brucellosis requires control of animal brucellosis, but evidence to inform the design of control programs in the developing world is needed. SUMMARY: Brucellosis causes substantial morbidity in human and animal populations. While improvements in diagnostic options for resource-limited settings and stronger evidence for optimal therapy should enhance identification and treatment of human brucellosis, prevention of human disease through control in animals remains paramount.

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Published In

Curr Opin Infect Dis

DOI

EISSN

1473-6527

Publication Date

October 2013

Volume

26

Issue

5

Start / End Page

404 / 412

Location

United States

Related Subject Headings

  • Zoonoses
  • Socioeconomic Factors
  • Neglected Diseases
  • Middle East
  • Microbiology
  • Livestock
  • Humans
  • Brucellosis
  • Asia
  • Animals
 

Citation

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Rubach, M. P., Halliday, J. E. B., Cleaveland, S., & Crump, J. A. (2013). Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis, 26(5), 404–412. https://doi.org/10.1097/QCO.0b013e3283638104
Rubach, Matthew P., Jo E. B. Halliday, Sarah Cleaveland, and John A. Crump. “Brucellosis in low-income and middle-income countries.Curr Opin Infect Dis 26, no. 5 (October 2013): 404–12. https://doi.org/10.1097/QCO.0b013e3283638104.
Rubach MP, Halliday JEB, Cleaveland S, Crump JA. Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis. 2013 Oct;26(5):404–12.
Rubach, Matthew P., et al. “Brucellosis in low-income and middle-income countries.Curr Opin Infect Dis, vol. 26, no. 5, Oct. 2013, pp. 404–12. Pubmed, doi:10.1097/QCO.0b013e3283638104.
Rubach MP, Halliday JEB, Cleaveland S, Crump JA. Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis. 2013 Oct;26(5):404–412.

Published In

Curr Opin Infect Dis

DOI

EISSN

1473-6527

Publication Date

October 2013

Volume

26

Issue

5

Start / End Page

404 / 412

Location

United States

Related Subject Headings

  • Zoonoses
  • Socioeconomic Factors
  • Neglected Diseases
  • Middle East
  • Microbiology
  • Livestock
  • Humans
  • Brucellosis
  • Asia
  • Animals