Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Published

Journal Article

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Full Text

Duke Authors

Dawson, Geraldine

Cited Authors

Cross-Disorder Group of the Psychiatric Genomics Consortium, ; Lee, SH; Ripke, S; Neale, BM; Faraone, SV; Purcell, SM; Perlis, RH; Mowry, BJ; Thapar, A; Goddard, ME; Witte, JS; Absher, D; Agartz, I; Akil, H; Amin, F; Andreassen, OA; Anjorin, A; Anney, R; Anttila, V; Arking, DE; Asherson, P; Azevedo, MH; Backlund, L; Badner, JA; Bailey, AJ; Banaschewski, T; Barchas, JD; Barnes, MR; Barrett, TB; Bass, N; Battaglia, A; Bauer, M; Bayés, M; Bellivier, F; Bergen, SE; Berrettini, W; Betancur, C; Bettecken, T; Biederman, J; Binder, EB; Black, DW; Blackwood, DHR; Bloss, CS; Boehnke, M; Boomsma, DI; Breen, G; Breuer, R; Bruggeman, R; Cormican, P; Buccola, NG; Buitelaar, JK; Bunney, WE; Buxbaum, JD; Byerley, WF; Byrne, EM; Caesar, S; Cahn, W; Cantor, RM; Casas, M; Chakravarti, A; Chambert, K; Choudhury, K; Cichon, S; Cloninger, CR; Collier, DA; Cook, EH; Coon, H; Cormand, B; Corvin, A; Coryell, WH; Craig, DW; Craig, IW; Crosbie, J; Cuccaro, ML; Curtis, D; Czamara, D; Datta, S; Dawson, G; Day, R; De Geus, EJ; Degenhardt, F; Djurovic, S; Donohoe, GJ; Doyle, AE; Duan, J; Dudbridge, F; Duketis, E; Ebstein, RP; Edenberg, HJ; Elia, J; Ennis, S; Etain, B; Fanous, A; Farmer, AE; Ferrier, IN; Flickinger, M; Fombonne, E; Foroud, T; Frank, J; Franke, B; Fraser, C; Freedman, R; Freimer, NB; Freitag, CM; Friedl, M; Frisén, L; Gallagher, L; Gejman, PV; Georgieva, L; Gershon, ES; Geschwind, DH; Giegling, I; Gill, M; Gordon, SD; Gordon-Smith, K; Green, EK; Greenwood, TA; Grice, DE; Gross, M; Grozeva, D; Guan, W; Gurling, H; De Haan, L; Haines, JL; Hakonarson, H; Hallmayer, J; Hamilton, SP; Hamshere, ML; Hansen, TF; Hartmann, AM; Hautzinger, M; Heath, AC; Henders, AK; Herms, S; Hickie, IB; Hipolito, M; Hoefels, S; Holmans, PA; Holsboer, F; Hoogendijk, WJ; Hottenga, J-J; Hultman, CM; Hus, V; Ingason, A; Ising, M; Jamain, S; Jones, EG; Jones, I; Jones, L; Tzeng, J-Y; Kähler, AK; Kahn, RS; Kandaswamy, R; Keller, MC; Kennedy, JL; Kenny, E; Kent, L; Kim, Y; Kirov, GK; Klauck, SM; Klei, L; Knowles, JA; Kohli, MA; Koller, DL; Konte, B; Korszun, A; Krabbendam, L; Krasucki, R; Kuntsi, J; Kwan, P; Landén, M; Långström, N; Lathrop, M; Lawrence, J; Lawson, WB; Leboyer, M; Ledbetter, DH; Lee, PH; Lencz, T; Lesch, K-P; Levinson, DF; Lewis, CM; Li, J; Lichtenstein, P; Lieberman, JA; Lin, D-Y; Linszen, DH; Liu, C; Lohoff, FW; Loo, SK; Lord, C; Lowe, JK; Lucae, S; MacIntyre, DJ; Madden, PAF; Maestrini, E; Magnusson, PKE; Mahon, PB; Maier, W; Malhotra, AK; Mane, SM; Martin, CL; Martin, NG; Mattheisen, M; Matthews, K; Mattingsdal, M; McCarroll, SA; McGhee, KA; McGough, JJ; McGrath, PJ; McGuffin, P; McInnis, MG; McIntosh, A; McKinney, R; McLean, AW; McMahon, FJ; McMahon, WM; McQuillin, A; Medeiros, H; Medland, SE; Meier, S; Melle, I; Meng, F; Meyer, J; Middeldorp, CM; Middleton, L; Milanova, V; Miranda, A; Monaco, AP; Montgomery, GW; Moran, JL; Moreno-De-Luca, D; Morken, G; Morris, DW; Morrow, EM; Moskvina, V; Muglia, P; Mühleisen, TW; Muir, WJ; Müller-Myhsok, B; Murtha, M; Myers, RM; Myin-Germeys, I; Neale, MC; Nelson, SF; Nievergelt, CM; Nikolov, I; Nimgaonkar, V; Nolen, WA; Nöthen, MM; Nurnberger, JI; Nwulia, EA; Nyholt, DR; O'Dushlaine, C; Oades, RD; Olincy, A; Oliveira, G; Olsen, L; Ophoff, RA; Osby, U; Owen, MJ; Palotie, A; Parr, JR; Paterson, AD; Pato, CN; Pato, MT; Penninx, BW; Pergadia, ML; Pericak-Vance, MA; Pickard, BS; Pimm, J; Piven, J; Posthuma, D; Potash, JB; Poustka, F; Propping, P; Puri, V; Quested, DJ; Quinn, EM; Ramos-Quiroga, JA; Rasmussen, HB; Raychaudhuri, S; Rehnström, K; Reif, A; Ribasés, M; Rice, JP; Rietschel, M; Roeder, K; Roeyers, H; Rossin, L; Rothenberger, A; Rouleau, G; Ruderfer, D; Rujescu, D; Sanders, AR; Sanders, SJ; Santangelo, SL; Sergeant, JA; Schachar, R; Schalling, M; Schatzberg, AF; Scheftner, WA; Schellenberg, GD; Scherer, SW; Schork, NJ; Schulze, TG; Schumacher, J; Schwarz, M; Scolnick, E; Scott, LJ; Shi, J; Shilling, PD; Shyn, SI; Silverman, JM; Slager, SL; Smalley, SL; Smit, JH; Smith, EN; Sonuga-Barke, EJS; St Clair, D; State, M; Steffens, M; Steinhausen, H-C; Strauss, JS; Strohmaier, J; Stroup, TS; Sutcliffe, JS; Szatmari, P; Szelinger, S; Thirumalai, S; Thompson, RC; Todorov, AA; Tozzi, F; Treutlein, J; Uhr, M; van den Oord, EJCG; Van Grootheest, G; Van Os, J; Vicente, AM; Vieland, VJ; Vincent, JB; Visscher, PM; Walsh, CA; Wassink, TH; Watson, SJ; Weissman, MM; Werge, T; Wienker, TF; Wijsman, EM; Willemsen, G; Williams, N; Willsey, AJ; Witt, SH; Xu, W; Young, AH; Yu, TW; Zammit, S; Zandi, PP; Zhang, P; Zitman, FG; Zöllner, S; Devlin, B; Kelsoe, JR; Sklar, P; Daly, MJ; O'Donovan, MC; Craddock, N; Sullivan, PF; Smoller, JW; Kendler, KS; Wray, NR; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC),

Published Date

September 2013

Published In

Nat Genet

Volume / Issue

45 / 9

Start / End Page

984 - 994

PubMed ID

23933821

Pubmed Central ID

23933821

Electronic International Standard Serial Number (EISSN)

1546-1718

Digital Object Identifier (DOI)

10.1038/ng.2711

Language

Conference Location

United States

Scholars@Duke