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Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.

Publication ,  Journal Article
Chua, EC-P; Shui, G; Lee, IT-G; Lau, P; Tan, L-C; Yeo, S-C; Lam, BD; Bulchand, S; Summers, SA; Puvanendran, K; Rozen, SG; Wenk, MR; Gooley, JJ
Published in: Proc Natl Acad Sci U S A
August 27, 2013

The circadian system regulates daily rhythms in lipid metabolism and adipose tissue function. Although disruption of circadian clock function is associated with negative cardiometabolic end points, very little is known about interindividual variation in circadian-regulated metabolic pathways. Here, we used targeted lipidomics-based approaches to profile the time course of 263 lipids in blood plasma in 20 healthy individuals. Over a span of 28 h, blood was collected every 4 h and plasma lipids were analyzed by HPLC/MS. Across subjects, about 13% of lipid metabolites showed circadian variation. Rhythmicity spanned all metabolite classes examined, suggesting widespread circadian control of lipid-mediated energy storage, transport, and signaling. Intersubject agreement for lipids identified as rhythmic was only about 20%, however, and the timing of lipid rhythms ranged up to 12 h apart between individuals. Healthy subjects therefore showed substantial variation in the timing and strength of rhythms across different lipid species. Strong interindividual differences were also observed for rhythms of blood glucose and insulin, but not cortisol. Using consensus clustering with iterative feature selection, subjects clustered into different groups based on strength of rhythmicity for a subset of triglycerides and phosphatidylcholines, suggesting that there are different circadian metabolic phenotypes in the general population. These results have potential implications for lipid metabolism disorders linked to circadian clock disruption.

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

August 27, 2013

Volume

110

Issue

35

Start / End Page

14468 / 14473

Location

United States

Related Subject Headings

  • Young Adult
  • Phenotype
  • Mass Spectrometry
  • Male
  • Lipids
  • Insulin
  • Humans
  • Circadian Rhythm
  • Chromatography, High Pressure Liquid
  • Blood Glucose
 

Citation

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Chua, E.-P., Shui, G., Lee, I.-G., Lau, P., Tan, L.-C., Yeo, S.-C., … Gooley, J. J. (2013). Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A, 110(35), 14468–14473. https://doi.org/10.1073/pnas.1222647110
Chua, Eric Chern-Pin, Guanghou Shui, Ivan Tian-Guang Lee, Pauline Lau, Luuan-Chin Tan, Sing-Chen Yeo, Buu Duyen Lam, et al. “Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.Proc Natl Acad Sci U S A 110, no. 35 (August 27, 2013): 14468–73. https://doi.org/10.1073/pnas.1222647110.
Chua EC-P, Shui G, Lee IT-G, Lau P, Tan L-C, Yeo S-C, et al. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14468–73.
Chua, Eric Chern-Pin, et al. “Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.Proc Natl Acad Sci U S A, vol. 110, no. 35, Aug. 2013, pp. 14468–73. Pubmed, doi:10.1073/pnas.1222647110.
Chua EC-P, Shui G, Lee IT-G, Lau P, Tan L-C, Yeo S-C, Lam BD, Bulchand S, Summers SA, Puvanendran K, Rozen SG, Wenk MR, Gooley JJ. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14468–14473.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

August 27, 2013

Volume

110

Issue

35

Start / End Page

14468 / 14473

Location

United States

Related Subject Headings

  • Young Adult
  • Phenotype
  • Mass Spectrometry
  • Male
  • Lipids
  • Insulin
  • Humans
  • Circadian Rhythm
  • Chromatography, High Pressure Liquid
  • Blood Glucose