Genomics of varicose veins and chronic venous insufficiency.

Published

Journal Article

Recent sequencing of the human genome has opened up new areas of investigation for genetic aberrations responsible for the pathogenesis of many human diseases. To date, there have been no studies that have investigated the entire human genome for the genetic underpinnings of chronic venous insufficiency (CVI). Utilizing Gene Chip Arrays we analyzed the relative expression levels of more than 47,000 transcripts and variants and approximately 38,500 well-characterized genes from each of 20 patients (N (CVI)=10; N (Control Group)=10). Relative gene expression profiles significantly differed between patients with CVI and patients unaffected by CVI. Regulatory genes of mediators of the inflammatory reaction and collagen production were up-regulated and down-regulated, respectively in CVI patients. DNA microarray analysis also showed that relative gene expression of multiple genes which function remains to be elucidated was significantly different in CVI patients. Fundamental advancements in our knowledge of the human genome and understanding of the genetic basis of CVI represents an opportunity to develop new diagnostic, prognostic, preventive and therapeutic modalities in the management of CVI.

Full Text

Duke Authors

Cited Authors

  • Markovic, JN; Shortell, CK

Published Date

  • March 2013

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 2 - 13

PubMed ID

  • 23932556

Pubmed Central ID

  • 23932556

Electronic International Standard Serial Number (EISSN)

  • 1558-4518

Digital Object Identifier (DOI)

  • 10.1053/j.semvascsurg.2013.04.003

Language

  • eng

Conference Location

  • United States