Leukocytospermia: Overview of diagnosis, implications, and management of a controversial finding


Journal Article (Review)

Background The progress in assisted reproductive techniques over the last 30 years has raised interest in studying what in 1992 the World Health Organization (WHO) defined as abnormal: the presence of >1 × 10 6 leukocytes/mL in a semen sample. Leukocytospermia is found in both fertile and infertile men with and without evidence of infections of the genital tract. However, despite extensive research done in this subject, the clinical implications of this condition remain unclear. Results The accuracy that the cut-off value that defines leukocytospermia has in predicting clinical significance remains unclear. Furthermore, there are conflicting data supporting a physiologic and pathologic role of leukocytes in a semen sample through the generation of reactive oxygen species. Although some authors describe no effects on fertilization and pregnancy outcomes after in vitro fertilization with or without intra-cytoplasmic sperm injection, others suggest the exact opposite. Finally, research on treatment of leukocytospermia with vitamin E, COX-2 inhibitors and antibiotics has also shown contradicting data. Conclusions Thus, it seems reasonable to agree that there is no agreement on the diagnosis, implications, and management of leukocytospermia in patients without evidence of genital tract infection. © 2013 Production and hosting by Elsevier B.V. on behalf of Middle East Fertility Society.

Full Text

Duke Authors

Cited Authors

  • Sandoval, JS; Raburn, D; Muasher, S

Published Date

  • September 1, 2013

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 129 - 134

Electronic International Standard Serial Number (EISSN)

  • 2090-3251

International Standard Serial Number (ISSN)

  • 1110-5690

Digital Object Identifier (DOI)

  • 10.1016/j.mefs.2013.02.004

Citation Source

  • Scopus