Crystallization of asymmetric patchy models for globular proteins in solution.

Journal Article

Asymmetric patchy particle models have recently been shown to describe the crystallization of small globular proteins with near-quantitative accuracy. Here, we investigate how asymmetry in patch geometry and bond energy generally impacts the phase diagram and nucleation dynamics of this family of soft matter models. We find the role of the geometry asymmetry to be weak, but the energy asymmetry to markedly interfere with the crystallization thermodynamics and kinetics. These results provide a rationale for the success and occasional failure of the proposal of George and Wilson for protein crystallization conditions as well as physical guidance for developing more effective protein crystallization strategies.

Full Text

Duke Authors

Cited Authors

  • Fusco, D; Charbonneau, P

Published Date

  • July 18, 2013

Published In

Volume / Issue

  • 88 / 1

Start / End Page

  • 012721 -

PubMed ID

  • 23944504

Pubmed Central ID

  • 23944504

Electronic International Standard Serial Number (EISSN)

  • 1550-2376

International Standard Serial Number (ISSN)

  • 1539-3755

Digital Object Identifier (DOI)

  • 10.1103/physreve.88.012721

Language

  • eng