What is the optimum adjunctive reperfusion strategy for primary percutaneous coronary intervention?
Journal Article (Journal Article;Review)
Acute ST-segment elevation myocardial infarction (STEMI) is a dynamic, thrombus-driven event. As understanding of its pathophysiology has improved, the central role of platelets in initiation and orchestration of this process has become clear. Key components of STEMI include formation of occlusive thrombus, mediation and ultimately amplification of the local vascular inflammatory response resulting in increased vasoreactivity, oedema formation, and microvascular obstruction. Activation, degranulation, and aggregation of platelets are the platforms from which these components develop. Therefore, prompt, potent, and predictable antithrombotic therapy is needed to optimise clinical outcomes after primary percutaneous coronary intervention. We review present pharmacological and mechanical adjunctive therapies for reperfusion and ask what is the optimum combination when primary percutaneous coronary intervention is used as the mode of revascularisation in patients with STEMI.
Full Text
Duke Authors
Cited Authors
- Curzen, N; Gurbel, PA; Myat, A; Bhatt, DL; Redwood, SR
Published Date
- August 17, 2013
Published In
Volume / Issue
- 382 / 9892
Start / End Page
- 633 - 643
PubMed ID
- 23953387
Electronic International Standard Serial Number (EISSN)
- 1474-547X
Digital Object Identifier (DOI)
- 10.1016/S0140-6736(13)61453-1
Language
- eng
Conference Location
- England