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Inflammation and atherosclerosis: disease modulating therapies.

Publication ,  Journal Article
Patel, MJ; Blazing, MA
Published in: Curr Treat Options Cardiovasc Med
December 2013

Advances in the mechanistic understanding of atheroma initiation, repair, progression, and rupture have solidified the pivotal role played by the immune system in the pathophysiology of atherosclerotic vascular disease. These mechanistic findings have been extended into humans, with a strong evidence basis for the independent association between elevated blood markers of inflammation and future cardiovascular (CV) events. Investigations with statins as well as more conventional anti-inflammatory medications provide indirect evidence to support the concept that modifying immune responses can improve CV outcomes; however, robust evidence to support the use of anti-inflammatory treatment strategies to manage atherosclerotic vascular disease is still lacking. Such evidence may emerge from a new wave of clinical trials directly exploring the effects of targeted immune modulation on CV risk. These trials will provide key additional insights into atherosclerosis and will help determine the fate of immune modulation as a new treatment strategy in atherosclerotic vascular disease.

Duke Scholars

Published In

Curr Treat Options Cardiovasc Med

DOI

ISSN

1092-8464

Publication Date

December 2013

Volume

15

Issue

6

Start / End Page

681 / 695

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, M. J., & Blazing, M. A. (2013). Inflammation and atherosclerosis: disease modulating therapies. Curr Treat Options Cardiovasc Med, 15(6), 681–695. https://doi.org/10.1007/s11936-013-0268-z
Patel, Mahesh J., and Michael A. Blazing. “Inflammation and atherosclerosis: disease modulating therapies.Curr Treat Options Cardiovasc Med 15, no. 6 (December 2013): 681–95. https://doi.org/10.1007/s11936-013-0268-z.
Patel MJ, Blazing MA. Inflammation and atherosclerosis: disease modulating therapies. Curr Treat Options Cardiovasc Med. 2013 Dec;15(6):681–95.
Patel, Mahesh J., and Michael A. Blazing. “Inflammation and atherosclerosis: disease modulating therapies.Curr Treat Options Cardiovasc Med, vol. 15, no. 6, Dec. 2013, pp. 681–95. Pubmed, doi:10.1007/s11936-013-0268-z.
Patel MJ, Blazing MA. Inflammation and atherosclerosis: disease modulating therapies. Curr Treat Options Cardiovasc Med. 2013 Dec;15(6):681–695.

Published In

Curr Treat Options Cardiovasc Med

DOI

ISSN

1092-8464

Publication Date

December 2013

Volume

15

Issue

6

Start / End Page

681 / 695

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology