Spatial coordination between stem cell activity and cell differentiation in the root meristem.

Journal Article (Journal Article)

A critical issue in development is the coordination of the activity of stem cell niches with differentiation of their progeny to ensure coherent organ growth. In the plant root, these processes take place at opposite ends of the meristem and must be coordinated with each other at a distance. Here, we show that in Arabidopsis, the gene SCR presides over this spatial coordination. In the organizing center of the root stem cell niche, SCR directly represses the expression of the cytokinin-response transcription factor ARR1, which promotes cell differentiation, controlling auxin production via the ASB1 gene and sustaining stem cell activity. This allows SCR to regulate, via auxin, the level of ARR1 expression in the transition zone where the stem cell progeny leaves the meristem, thus controlling the rate of differentiation. In this way, SCR simultaneously controls stem cell division and differentiation, ensuring coherent root growth.

Full Text

Duke Authors

Cited Authors

  • Moubayidin, L; Di Mambro, R; Sozzani, R; Pacifici, E; Salvi, E; Terpstra, I; Bao, D; van Dijken, A; Dello Ioio, R; Perilli, S; Ljung, K; Benfey, PN; Heidstra, R; Costantino, P; Sabatini, S

Published Date

  • August 2013

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 405 - 415

PubMed ID

  • 23987513

Pubmed Central ID

  • PMC4839959

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2013.06.025


  • eng