Understanding and targeting resistance to anti-angiogenic therapies.
Published
Journal Article
Therapies targeting tumor angiogenesis are used in a variety of malignancies, however not all patients benefit from treatment and impact on tumor control may be transient and modest. Mechanisms of resistance to anti-angiogenic therapies can be broadly categorized into VEGF-axis dependent alterations, non-VEGF pathways, and stromal cell interactions. Complimentary combinations of agents that inhibit alternative mechanisms of blood vessel formation may optimize inhibition of angiogenesis and improve clinical benefit for patients. The purpose of this review is to detail the preclinical evidence for mechanisms of angiogenic resistance and provide an overview of novel therapeutic approaches exploiting these pathways.
Full Text
Duke Authors
Cited Authors
- Clarke, JM; Hurwitz, HI
Published Date
- September 2013
Published In
Volume / Issue
- 4 / 3
Start / End Page
- 253 - 263
PubMed ID
- 23997938
Pubmed Central ID
- 23997938
International Standard Serial Number (ISSN)
- 2078-6891
Digital Object Identifier (DOI)
- 10.3978/j.issn.2078-6891.2013.036
Language
- eng
Conference Location
- China