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Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy.

Publication ,  Journal Article
Cohen, EEW; Ahmed, O; Kocherginsky, M; Shustakova, G; Kistner-Griffin, E; Salama, JK; Yefremenko, V; Novosad, V
Published in: Oral Oncol
October 2013

BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) has led to improved efficacy in treating locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) but has led to almost universal in-field mucositis. Patients treated with the same regimen often have differences in mucositis occurrence and severity. Mucositis induced via radiation is known to represent an intense inflammatory response histologically. We hypothesized that patients destined to display severe mucocutaneous toxicity would demonstrate greater alterations in thermal intensity early in therapy than identically treated counterparts. This will allow identification of patients that will require more intensive supportive care using thermal imaging technology. MATERIALS AND METHODS: Subjects with LA-SCCHN (oral cavity or oropharynx) being treated with the identical chemoradiotherapy regimen underwent baseline and weekly thermal imaging. Changes in skin temperature caused by mucositis and dermatitis compared with a reference area (ΔT were calculated and correlated to grade of mucositis based on NCI-CTCAE 3.0. RESULTS: Thirty-four subjects were enrolled. Grade 3 mucositis and dermatitis was observed in 53% and 21%, respectively. We observed a statistically significant positive association between an early rise in ΔT and mucositis grade (p value=0.03). CONCLUSIONS: Thermal imaging is able to detect small and early changes in skin surface temperature that may be associated with development of mucositis in patients being treated with chemoradiotherapy.

Duke Scholars

Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

October 2013

Volume

49

Issue

10

Start / End Page

1025 / 1031

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Radiodermatitis
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Mucositis
  • Mouth Neoplasms
  • Middle Aged
  • Male
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Cohen, E. E. W., Ahmed, O., Kocherginsky, M., Shustakova, G., Kistner-Griffin, E., Salama, J. K., … Novosad, V. (2013). Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy. Oral Oncol, 49(10), 1025–1031. https://doi.org/10.1016/j.oraloncology.2013.07.009
Cohen, Ezra E. W., Omar Ahmed, Masha Kocherginsky, Galyna Shustakova, Emily Kistner-Griffin, Joseph K. Salama, Volodymyr Yefremenko, and Valentyn Novosad. “Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy.Oral Oncol 49, no. 10 (October 2013): 1025–31. https://doi.org/10.1016/j.oraloncology.2013.07.009.
Cohen EEW, Ahmed O, Kocherginsky M, Shustakova G, Kistner-Griffin E, Salama JK, et al. Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy. Oral Oncol. 2013 Oct;49(10):1025–31.
Cohen, Ezra E. W., et al. “Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy.Oral Oncol, vol. 49, no. 10, Oct. 2013, pp. 1025–31. Pubmed, doi:10.1016/j.oraloncology.2013.07.009.
Cohen EEW, Ahmed O, Kocherginsky M, Shustakova G, Kistner-Griffin E, Salama JK, Yefremenko V, Novosad V. Study of functional infrared imaging for early detection of mucositis in locally advanced head and neck cancer treated with chemoradiotherapy. Oral Oncol. 2013 Oct;49(10):1025–1031.
Journal cover image

Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

October 2013

Volume

49

Issue

10

Start / End Page

1025 / 1031

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Radiodermatitis
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Mucositis
  • Mouth Neoplasms
  • Middle Aged
  • Male
  • Humans