Is conflict of interest becoming a challenge for institution-based institutional review boards?
Expansion of business relationships between academic institutions and their leaders and industry have become a reality, whereas media attention regarding conflict of interest (COI) at academic institutions has raised concerns about possible erosion of public trust. The Institutional Review Board (IRB) should collaborate with institutional COI committees to ensure that research with human subjects is in compliance with various applicable federal regulations. The IRB and COI committee should take additional independent action as necessary under their separate mandates to protect the welfare, safety, and rights of human subjects and to include limits on protocols affected by significant financial interests of the institution or its decision makers. If unable to review research due to an intrainstitutional conflict, the local IRB should consider transferring the study review and oversight to an external unaffiliated institutional or central IRB. A process for involvement of an executive institutional IRB is proposed.
Duke Scholars
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- Research
- Oncology & Carcinogenesis
- Humans
- Drug Industry
- Drug Approval
- Conflict of Interest
- Commerce
- Academies and Institutes
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Research
- Oncology & Carcinogenesis
- Humans
- Drug Industry
- Drug Approval
- Conflict of Interest
- Commerce
- Academies and Institutes
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences