New targeted therapies and other advances in the management of anaplastic thyroid cancer.


Journal Article (Review)

Anaplastic thyroid cancer is the most aggressive solid tumor known to humans. Even when found in a localized form, the prognosis is grave. For metastatic disease, there has been little effect on survival using traditional chemotherapy.Over a five-decade interval, there has been little progress in the treatment of this malignancy. However, targeted agents represent a new mode of treatment, and some studies have shown encouraging preclinical results. Combretastatin has shown activity in phase 1 and phase II trials; although the registration phase III study failed to meet its accrual goals, it did appear to show some benefit, especially in younger patients.Combinations of this compound and other targeted agents may prove to be a breakthrough in an otherwise untreatable cancer.

Full Text

Cited Authors

  • Deshpande, HA; Roman, S; Sosa, JA

Published Date

  • January 2013

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 44 - 49

PubMed ID

  • 23159847

Pubmed Central ID

  • 23159847

Electronic International Standard Serial Number (EISSN)

  • 1531-703X

International Standard Serial Number (ISSN)

  • 1040-8746

Digital Object Identifier (DOI)

  • 10.1097/cco.0b013e32835a448c


  • eng