Medullary thyroid carcinoma without marked elevation of calcitonin: a diagnostic and surveillance dilemma.


Journal Article

Calcitonin is a sensitive tumor marker for medullary thyroid cancer (MTC) and is useful in preoperative diagnosis and postoperative surveillance for recurrent disease. Calcitonin-negative MTC is a rare occurrence. We present the case of a 68-year-old man with a 6.5 cm sporadic MTC with a 5-cm metastasis in the neck, but only minimally elevated serum calcitonin levels. He underwent total thyroidectomy, resection of internal jugular vein, and limited ipsilateral lymph node dissection. He remains disease-free 12 months after surgery. We review the literature on calcitonin-negative MTC and discuss methods of postoperative surveillance in this subset of patients.

Full Text

Cited Authors

  • Wang, TS; Ocal, IT; Sosa, JA; Cox, H; Roman, S

Published Date

  • August 2008

Published In

Volume / Issue

  • 18 / 8

Start / End Page

  • 889 - 894

PubMed ID

  • 18651827

Pubmed Central ID

  • 18651827

Electronic International Standard Serial Number (EISSN)

  • 1557-9077

International Standard Serial Number (ISSN)

  • 1050-7256

Digital Object Identifier (DOI)

  • 10.1089/thy.2007.0413


  • eng