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Adapting smoking cessation treatment according to initial response to precessation nicotine patch.

Publication ,  Journal Article
Rose, JE; Behm, FM
Published in: Am J Psychiatry
August 2013

OBJECTIVE The authors evaluated an adaptive smoking cessation treatment strategy in which nicotine patch treatment was initiated before a quit date, and then, depending on initial therapeutic response, either the nicotine patch was continued or alternative pharmacotherapies were provided. METHOD The study was a double-blind, parallel-arm adaptive treatment trial. A total of 606 cigarette smokers started open-label nicotine patch treatment 2 weeks before the quit date. Those whose ad lib smoking did not decrease by >50% after 1 week were randomly assigned to one of three double-blind treatments: nicotine patch alone (control condition); "rescue" treatment with bupropion augmentation of the patch; or rescue treatment with varenicline alone. Participants whose precessation smoking decreased >50% but who lapsed after the quit date were also randomly assigned to the two rescue treatments or to nicotine patch alone. Logistic regression analyses compared each rescue treatment against the control condition in terms of abstinence at the end of treatment (weeks 8-11) and at 6 months. RESULTS Smokers who did not respond adequately to precessation nicotine patch benefited from bupropion augmentation; abstinence rates at end of treatment were 16% with nicotine patch alone and 28% with bupropion augmentation (odds ratio=2.04, 95% CI=1.03-4.01). Switching to varenicline produced less robust effects, but point abstinence at 6 months was 6.6% with the patch alone and 16.5% with a switch to varenicline (odds ratio=2.80, 95% CI=1.11-7.06). Postquit adaptive changes in treatment had no significant effects on any abstinence outcome. CONCLUSIONS It is possible to rescue a significant portion of smokers who would have failed to achieve abstinence if left on nicotine patch alone by identifying these smokers before their quit date and implementing adaptive changes in treatment.

Duke Scholars

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Published In

Am J Psychiatry

DOI

EISSN

1535-7228

Publication Date

August 2013

Volume

170

Issue

8

Start / End Page

860 / 867

Location

United States

Related Subject Headings

  • Varenicline
  • Treatment Outcome
  • Tobacco Use Disorder
  • Tobacco Use Cessation Devices
  • Smoking Cessation
  • Quinoxalines
  • Psychiatry
  • Premedication
  • Nicotinic Agonists
  • Middle Aged
 

Citation

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Rose, J. E., & Behm, F. M. (2013). Adapting smoking cessation treatment according to initial response to precessation nicotine patch. Am J Psychiatry, 170(8), 860–867. https://doi.org/10.1176/appi.ajp.2013.12070919
Rose, Jed E., and Frédérique M. Behm. “Adapting smoking cessation treatment according to initial response to precessation nicotine patch.Am J Psychiatry 170, no. 8 (August 2013): 860–67. https://doi.org/10.1176/appi.ajp.2013.12070919.
Rose, Jed E., and Frédérique M. Behm. “Adapting smoking cessation treatment according to initial response to precessation nicotine patch.Am J Psychiatry, vol. 170, no. 8, Aug. 2013, pp. 860–67. Pubmed, doi:10.1176/appi.ajp.2013.12070919.
Journal cover image

Published In

Am J Psychiatry

DOI

EISSN

1535-7228

Publication Date

August 2013

Volume

170

Issue

8

Start / End Page

860 / 867

Location

United States

Related Subject Headings

  • Varenicline
  • Treatment Outcome
  • Tobacco Use Disorder
  • Tobacco Use Cessation Devices
  • Smoking Cessation
  • Quinoxalines
  • Psychiatry
  • Premedication
  • Nicotinic Agonists
  • Middle Aged