Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.


Journal Article

This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same phenotypes in their children. Our results reveal 3 characteristic groups of relationships among phenotypes in parents and children. One group composed of 3 pairs of phenotypes confirms that associations among some phenotypes can be explained by the same biogenetic mechanisms working in parents and children. Two other groups including 9 phenotype pairs show that this is not a common rule. Our findings suggest that biogenetic mechanisms underlying relationships among different phenotypes, even if they are causally related, can function differently in successive generations or in different age groups of biologically related individuals. The results suggest that the role of aging-related processes in changing environment may be conceptually underestimated in current genetic association studies using genome wide resources.

Full Text

Duke Authors

Cited Authors

  • Kulminski, AM; Arbeev, KG; Christensen, K; Stallard, E; Miljkovic, I; Barmada, M; Yashin, AI

Published Date

  • July 2013

Published In

Volume / Issue

  • 68 / 7

Start / End Page

  • 760 - 768

PubMed ID

  • 23213029

Pubmed Central ID

  • 23213029

Electronic International Standard Serial Number (EISSN)

  • 1758-535X

Digital Object Identifier (DOI)

  • 10.1093/gerona/gls243


  • eng

Conference Location

  • United States