Skeletal muscle microvasculature in the diagnosis of neuromuscular disease.

Journal Article (Journal Article;Review)

Blood vessels are often overlooked in analyses of skeletal muscle biopsies. However, there are many vascular features in skeletal muscle biopsies that, when interpreted in the context of other histologic patterns and clinical history, provide useful information that allows muscle pathologists to narrow their differential diagnoses and provide more accurate guidance to treating physicians. Here, we provide a review of normal skeletal muscle vasculature with details of the ultrastructure of vessel walls. We discuss the vascular effects of factors common to many patients undergoing muscle biopsy, for example, diabetes mellitus, hypertension, and aging. We then discuss vascular findings relevant to diagnostic muscle biopsy evaluation, with current theories of pathogenesis and detailed descriptions of the important features.

Full Text

Duke Authors

Cited Authors

  • Buckley, AF; Bossen, EH

Published Date

  • October 2013

Published In

Volume / Issue

  • 72 / 10

Start / End Page

  • 906 - 918

PubMed ID

  • 24042201

Electronic International Standard Serial Number (EISSN)

  • 1554-6578

Digital Object Identifier (DOI)

  • 10.1097/NEN.0b013e3182a7f0b8


  • eng

Conference Location

  • England