The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.
BACKGROUND AND PURPOSE: Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. METHODS: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case-control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. RESULTS: As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. CONCLUSIONS: The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.
Woo, D; Rosand, J; Kidwell, C; McCauley, JL; Osborne, J; Brown, MW; West, SE; Rademacher, EW; Waddy, S; Roberts, JN; Koch, S; Gonzales, NR; Sung, G; Kittner, SJ; Birnbaum, L; Frankel, M; Testai, FD; Hall, CE; Elkind, MSV; Flaherty, M; Coull, B; Chong, JY; Warwick, T; Malkoff, M; James, ML; Ali, LK; Worrall, BB; Jones, F; Watson, T; Leonard, A; Martinez, R; Sacco, RI; Langefeld, CD
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