Gadofosveset-enhanced magnetic resonance angiography of the thoracic vasculature in the equilibrium phase: feasibility and impact of dose.

Published

Journal Article

OBJECTIVE: The objectives of this study were to evaluate the feasibility of gadofosveset-enhanced magnetic resonance angiography (MRA) of the thoracic vasculature in the equilibrium phase and to determine the impact of gadofosveset dose on imaging quality. METHODS: Thirty healthy volunteers were randomized to receive a dose of 0.03, 0.02, or 0.01 mmol/kg of gadofosveset for MRA at 3 T in the equilibrium phase. Two radiologists assessed the central veins, the pulmonary arteries, and the thoracic aorta. Quantitative assessments were also performed. RESULTS: At 0.03 and 0.02 mmol/kg, all vessel segments were rated as adequate. At a dose of 0.01 mmol/kg, less than 10% of vascular segments were collectively rated as inadequate. The signal-to-noise ratio and contrast-to-noise ratio were significantly lower in all segments at 0.01 mmol/kg compared with higher doses. CONCLUSIONS: Gadofosveset-enhanced MRA of the thoracic vessels in the equilibrium phase in healthy volunteers resulted in adequate vessel visualization, even when dose reduction was performed.This trial was registered with clinicaltrials.gov, identifier NCT01431300.

Full Text

Duke Authors

Cited Authors

  • Kim, CY; Heye, T; Bashir, MR; Gebhard, TA; Merkle, EM

Published Date

  • September 2013

Published In

Volume / Issue

  • 37 / 5

Start / End Page

  • 732 - 736

PubMed ID

  • 24045249

Pubmed Central ID

  • 24045249

Electronic International Standard Serial Number (EISSN)

  • 1532-3145

Digital Object Identifier (DOI)

  • 10.1097/RCT.0b013e318299dde9

Language

  • eng

Conference Location

  • United States