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The relationship of sleep with temperature and metabolic rate in a hibernating primate.

Publication ,  Journal Article
Krystal, AD; Schopler, B; Kobbe, S; Williams, C; Rakatondrainibe, H; Yoder, AD; Klopfer, P
Published in: PLoS One
2013

STUDY OBJECTIVES: It has long been suspected that sleep is important for regulating body temperature and metabolic-rate. Hibernation, a state of acute hypothermia and reduced metabolic-rate, offers a promising system for investigating those relationships. Prior studies in hibernating ground squirrels report that, although sleep occurs during hibernation, it manifests only as non-REM sleep, and only at relatively high temperatures. In our study, we report data on sleep during hibernation in a lemuriform primate, Cheirogaleus medius. As the only primate known to experience prolonged periods of hibernation and as an inhabitant of more temperate climates than ground squirrels, this animal serves as an alternative model for exploring sleep temperature/metabolism relationships that may be uniquely relevant to understanding human physiology. MEASUREMENTS AND RESULTS: We find that during hibernation, non-REM sleep is absent in Cheirogaleus. Rather, periods of REM sleep occur during periods of relatively high ambient temperature, a pattern opposite of that observed in ground squirrels. Like ground squirrels, however, EEG is marked by ultra-low voltage activity at relatively low metabolic-rates. CONCLUSIONS: These findings confirm a sleep-temperature/metabolism link, though they also suggest that the relationship of sleep stage with temperature/metabolism is flexible and may differ across species or mammalian orders. The absence of non-REM sleep suggests that during hibernation in Cheirogaleus, like in the ground squirrel, the otherwise universal non-REM sleep homeostatic response is greatly curtailed or absent. Lastly, ultra-low voltage EEG appears to be a cross-species marker for extremely low metabolic-rate, and, as such, may be an attractive target for research on hibernation induction.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e69914

Location

United States

Related Subject Headings

  • Sleep
  • Hibernation
  • General Science & Technology
  • Electroencephalography
  • Cheirogaleidae
  • Body Temperature
  • Animals
 

Citation

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Krystal, A. D., Schopler, B., Kobbe, S., Williams, C., Rakatondrainibe, H., Yoder, A. D., & Klopfer, P. (2013). The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One, 8(9), e69914. https://doi.org/10.1371/journal.pone.0069914
Krystal, Andrew D., Bobby Schopler, Susanne Kobbe, Cathy Williams, Hajanirina Rakatondrainibe, Anne D. Yoder, and Peter Klopfer. “The relationship of sleep with temperature and metabolic rate in a hibernating primate.PLoS One 8, no. 9 (2013): e69914. https://doi.org/10.1371/journal.pone.0069914.
Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, et al. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013;8(9):e69914.
Krystal, Andrew D., et al. “The relationship of sleep with temperature and metabolic rate in a hibernating primate.PLoS One, vol. 8, no. 9, 2013, p. e69914. Pubmed, doi:10.1371/journal.pone.0069914.
Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013;8(9):e69914.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e69914

Location

United States

Related Subject Headings

  • Sleep
  • Hibernation
  • General Science & Technology
  • Electroencephalography
  • Cheirogaleidae
  • Body Temperature
  • Animals