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Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

Publication ,  Journal Article
Hayes, MG; Urbanek, M; Hivert, M-F; Armstrong, LL; Morrison, J; Guo, C; Lowe, LP; Scheftner, DA; Pluzhnikov, A; Levine, DM; McHugh, CP ...
Published in: Diabetes
September 2013

Maternal metabolism during pregnancy impacts the developing fetus, affecting offspring birth weight and adiposity. This has important implications for metabolic health later in life (e.g., offspring of mothers with pre-existing or gestational diabetes mellitus have an increased risk of metabolic disorders in childhood). To identify genetic loci associated with measures of maternal metabolism obtained during an oral glucose tolerance test at ∼28 weeks' gestation, we performed a genome-wide association study of 4,437 pregnant mothers of European (n = 1,367), Thai (n = 1,178), Afro-Caribbean (n = 1,075), and Hispanic (n = 817) ancestry, along with replication of top signals in three additional European ancestry cohorts. In addition to identifying associations with genes previously implicated with measures of glucose metabolism in nonpregnant populations, we identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. These results suggest that the genetic architecture underlying glucose metabolism may differ, in part, in pregnancy.

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Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

September 2013

Volume

62

Issue

9

Start / End Page

3282 / 3291

Location

United States

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Humans
  • Glucose Tolerance Test
  • Genotype
  • Genome-Wide Association Study
  • Female
  • Fasting
  • Endocrinology & Metabolism
  • C-Peptide
 

Citation

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Hayes, M. G., Urbanek, M., Hivert, M.-F., Armstrong, L. L., Morrison, J., Guo, C., … HAPO Study Cooperative Research Group, . (2013). Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes, 62(9), 3282–3291. https://doi.org/10.2337/db12-1692
Hayes, M Geoffrey, Margrit Urbanek, Marie-France Hivert, Loren L. Armstrong, Jean Morrison, Cong Guo, Lynn P. Lowe, et al. “Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.Diabetes 62, no. 9 (September 2013): 3282–91. https://doi.org/10.2337/db12-1692.
Hayes MG, Urbanek M, Hivert M-F, Armstrong LL, Morrison J, Guo C, et al. Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes. 2013 Sep;62(9):3282–91.
Hayes, M. Geoffrey, et al. “Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.Diabetes, vol. 62, no. 9, Sept. 2013, pp. 3282–91. Pubmed, doi:10.2337/db12-1692.
Hayes MG, Urbanek M, Hivert M-F, Armstrong LL, Morrison J, Guo C, Lowe LP, Scheftner DA, Pluzhnikov A, Levine DM, McHugh CP, Ackerman CM, Bouchard L, Brisson D, Layden BT, Mirel D, Doheny KF, Leya MV, Lown-Hecht RN, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL, HAPO Study Cooperative Research Group. Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes. 2013 Sep;62(9):3282–3291.

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

September 2013

Volume

62

Issue

9

Start / End Page

3282 / 3291

Location

United States

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Humans
  • Glucose Tolerance Test
  • Genotype
  • Genome-Wide Association Study
  • Female
  • Fasting
  • Endocrinology & Metabolism
  • C-Peptide