Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy.

Journal Article (Review;Journal Article)

This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Fales, AM; Griffin, GD; Khoury, CG; Liu, Y; Ngo, H; Norton, SJ; Register, JK; Wang, H-N; Yuan, H

Published Date

  • November 2013

Published In

Volume / Issue

  • 5 / 21

Start / End Page

  • 10127 - 10140

PubMed ID

  • 24056945

Pubmed Central ID

  • PMC4355622

Electronic International Standard Serial Number (EISSN)

  • 2040-3372

International Standard Serial Number (ISSN)

  • 2040-3364

Digital Object Identifier (DOI)

  • 10.1039/c3nr03633b


  • eng