Safety and efficacy of intravenous combination sedatives in the ED.


Journal Article

OBJECTIVE: The objective of the study is to determine the safety of intravenously administered combination sedatives in the emergency department (ED). METHODS: This was a retrospective study of alcohol-intoxicated patients in the ED. We examined the incidence of adverse events in agitated patients who received combination sedatives intravenously and compared the efficacy of combination sedatives and single-agent sedatives. RESULTS: Of 1300 patient visits, there was a single adverse event, a dystonic reaction, in the combination sedative group, for an adverse event rate of less than 1%. Patients who received combination sedatives were less likely to require a second dose of sedative medication than patients who received a single-agent sedative (21% vs 44%). CONCLUSIONS: Combination sedatives appear to be safe when administered intravenously in the ED. Combination sedatives may be more effective than single-agent sedatives in agitated alcohol-intoxicated patients.

Full Text

Duke Authors

Cited Authors

  • Li, SF; Kumar, A; Thomas, S; Sorokina, Y; Calderon, V; Dubey, E; Lee, L; Gustave, L

Published Date

  • September 2013

Published In

Volume / Issue

  • 31 / 9

Start / End Page

  • 1402 - 1404

PubMed ID

  • 23928329

Pubmed Central ID

  • 23928329

Electronic International Standard Serial Number (EISSN)

  • 1532-8171

Digital Object Identifier (DOI)

  • 10.1016/j.ajem.2013.06.017


  • eng

Conference Location

  • United States