Idiopathic scoliosis in families of children with congenital scoliosis.


Journal Article

Although most cases of congenital scoliosis are thought to be of sporadic etiology, it is not known whether other types of spinal deformity occur in families of individuals with this type of scoliosis. Children with congenital scoliosis were identified through a review of health records and radiographic report databases. Of 237 children with congenital scoliosis investigated, 49 (20.7%) reported a family history of spinal deformity. Detailed pedigrees were done, which showed a history of idiopathic scoliosis in 17.3% of the 237 families. This is a higher than expected rate of spinal deformity in families of children with congenital scoliosis, and the strong association of idiopathic scoliosis in families of children with congenital scoliosis has not been reported previously. Although this finding could be related to the chance occurrence of multiple genetic abnormalities or sporadic events in these families, it does raise the possibility that one genetic defect at least predisposes these families to having different types of spinal deformity develop.

Full Text

Duke Authors

Cited Authors

  • Purkiss, SB; Driscoll, B; Cole, WG; Alman, B

Published Date

  • August 2002

Published In

Start / End Page

  • 27 - 31

PubMed ID

  • 12151879

Pubmed Central ID

  • 12151879

International Standard Serial Number (ISSN)

  • 0009-921X

Digital Object Identifier (DOI)

  • 10.1097/00003086-200208000-00005


  • eng

Conference Location

  • United States