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Etiology and treatment of fibrous dysplasia

Publication ,  Journal Article
Alman, BA
Published in: Current Opinion in Orthopaedics
January 1, 1997

Fibrous dysplasia is a benign bone lesion composed of a proliferation of spindle cells producing dysplastic bone. It occurs in a monostotic form, a polyostic form, or as part of McCune-Albright syndrome (polyostotic form with endocrinopathies). In all three cases, it is caused by a somatic activating mutation in the trimeric stimulatory guanine nucleotide binding protein, Gs. Treatment depends on the severity of involvement and location of the lesion and consists of observation, internal fixation to stabilize the bone, or osteotomies to correct mechanical deformity. Bisphosphonate therapy increases radiographic bone density and may be helpful in cases that are otherwise difficult to manage. Future treatment may be developed based on the molecular pathology of the Gs mutation.

Duke Scholars

Published In

Current Opinion in Orthopaedics

DOI

ISSN

1041-9918

Publication Date

January 1, 1997

Volume

8

Issue

5

Start / End Page

25 / 29

Related Subject Headings

  • Orthopedics
 

Citation

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Chicago
ICMJE
MLA
NLM
Alman, B. A. (1997). Etiology and treatment of fibrous dysplasia. Current Opinion in Orthopaedics, 8(5), 25–29. https://doi.org/10.1097/00001433-199710000-00005
Alman, B. A. “Etiology and treatment of fibrous dysplasia.” Current Opinion in Orthopaedics 8, no. 5 (January 1, 1997): 25–29. https://doi.org/10.1097/00001433-199710000-00005.
Alman BA. Etiology and treatment of fibrous dysplasia. Current Opinion in Orthopaedics. 1997 Jan 1;8(5):25–9.
Alman, B. A. “Etiology and treatment of fibrous dysplasia.” Current Opinion in Orthopaedics, vol. 8, no. 5, Jan. 1997, pp. 25–29. Scopus, doi:10.1097/00001433-199710000-00005.
Alman BA. Etiology and treatment of fibrous dysplasia. Current Opinion in Orthopaedics. 1997 Jan 1;8(5):25–29.

Published In

Current Opinion in Orthopaedics

DOI

ISSN

1041-9918

Publication Date

January 1, 1997

Volume

8

Issue

5

Start / End Page

25 / 29

Related Subject Headings

  • Orthopedics