Fracture failure mechanisms in patients with osteogenesis imperfecta
This investigation examines the failure mechanism of bone from patients with osteogenesis imperfecta (OI). Mechanical testing and ultrastructural analysis of surgically obtained bone specimens, from patients with OI and from approximately age matched normal controls, were performed. This study shows that a relatively simple mechanical test utilizing a small amount of bone can differentiate between a diseased state (OI) and a normal state of bone. With this knowledge it will be possible to focus research on the defect that leads to bone fractures and to suggest improvements in patient management.