Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat.

Published

Journal Article

OBJECTIVE: Excessive central fat puts one at greater risk of disease. In animal studies, stress-induced cortisol secretion has been shown to increase central fat. The objective of this study was to assess whether women with central fat distribution (as indicated by a high waist-to-hip ratio [WHR]), across a range of body mass indexes, display consistently heightened cortisol reactivity to repeated laboratory stressors. METHODS: Fifty-nine healthy premenopausal women, 30 with a high WHR and 29 with a low WHR, were exposed to consecutive laboratory sessions over 4 days (three stress sessions and one rest session). During these sessions, cortisol and psychological responses were assessed. RESULTS: Women with a high WHR evaluated the laboratory challenges as more threatening, performed more poorly on them, and reported more chronic stress. These women secreted significantly more cortisol during the first stress session than women with a low WHR. Furthermore, lean women with a high WHR lacked habituation to stress in that they continued to secrete significantly more cortisol in response to now familiar challenges (days 2 and 3) than lean women with a low WHR. CONCLUSIONS: Central fat distribution is related to greater psychological vulnerability to stress and cortisol reactivity. This may be especially true among lean women, who did not habituate to repeated stress. The current cross-sectional findings support the hypothesis that stress-induced cortisol secretion may contribute to central fat and demonstrate a link between psychological stress and risk for disease.

Full Text

Duke Authors

Cited Authors

  • Epel, ES; McEwen, B; Seeman, T; Matthews, K; Castellazzo, G; Brownell, KD; Bell, J; Ickovics, JR

Published Date

  • September 2000

Published In

Volume / Issue

  • 62 / 5

Start / End Page

  • 623 - 632

PubMed ID

  • 11020091

Pubmed Central ID

  • 11020091

Electronic International Standard Serial Number (EISSN)

  • 1534-7796

International Standard Serial Number (ISSN)

  • 0033-3174

Digital Object Identifier (DOI)

  • 10.1097/00006842-200009000-00005

Language

  • eng