The double-blind in danger: untoward consequences of informed consent.

Journal Article (Clinical Trial;Journal Article)

Patients and physicians correctly identified medication assignments in 70% of the cases in a double-blind trial of an appetite suppressant. The breach of the double-blind design may have had therapeutic consequences; correct identification was associated with favorable outcome. These findings suggest that requirements for describing the side effects of medications to patients before they give informed consent may help them guess which medication they receive and thus may influence the integrity of double-blind studies and the results of controLled trials.

Full Text

Duke Authors

Cited Authors

  • Brownell, KD; Stunkard, AJ

Published Date

  • November 1, 1982

Published In

Volume / Issue

  • 139 / 11

Start / End Page

  • 1487 - 1489

PubMed ID

  • 6753613

Electronic International Standard Serial Number (EISSN)

  • 1535-7228

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.139.11.1487


  • eng