Kinetic model parameter estimates of liver FDG metabolism
Journal Article (Journal Article)
Liver kinetic studies of [18F]2-fluoro-2-deoxy-D-glucose (FDG) metabolism are important tools for functional information modeling and hepatic glucose metabolic rate estimates. Kinetic parameter estimates require the arterial blood time-activity curve and the tissue time-activity curve as input and output functions. For liver studies, however, the conventional arterial-input may not be consistent with the real model input because the liver has a dual blood supply from the hepatic artery and the portal vein to the liver. This study compares model parameter estimates using a dual-input function with results using an arterial-input function. The results show that the two methods provide different parameter estimates with the dual-input function leading to more accurate parameter estimates.
Duke Authors
Cited Authors
- Cui, Y; Bai, J; Chen, Y; Tian, J
Published Date
- March 1, 2007
Published In
Volume / Issue
- 47 / 3
Start / End Page
- 420 - 423
International Standard Serial Number (ISSN)
- 1000-0054
Citation Source
- Scopus