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Physiological and histopathological responses following closed rotational head injury depend on direction of head motion.

Publication ,  Journal Article
Eucker, SA; Smith, C; Ralston, J; Friess, SH; Margulies, SS
Published in: Exp Neurol
January 2011

Rotational inertial forces are thought to be the underlying mechanism for most severe brain injuries. However, little is known about the effect of head rotation direction on injury outcomes, particularly in the pediatric population. Neonatal piglets were subjected to a single non-impact head rotation in the horizontal, coronal, or sagittal direction, and physiological and histopathological responses were observed. Sagittal rotation produced the longest duration of unconsciousness, highest incidence of apnea, and largest intracranial pressure increase, while coronal rotation produced little change, and horizontal rotation produced intermediate and variable derangements. Significant cerebral blood flow reductions were observed following sagittal but not coronal or horizontal injury compared to sham. Subarachnoid hemorrhage, ischemia, and brainstem pathology were observed in the sagittal and horizontal groups but not in a single coronal animal. Significant axonal injury occurred following both horizontal and sagittal rotations. For both groups, the distribution of injury was greater in the frontal and parietotemporal lobes than in the occipital lobes, frequently occurred in the absence of ischemia, and did not correlate with regional cerebral blood flow reductions. We postulate that these direction-dependent differences in injury outcomes are due to differences in tissue mechanical loading produced during head rotation.

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Published In

Exp Neurol

DOI

EISSN

1090-2430

Publication Date

January 2011

Volume

227

Issue

1

Start / End Page

79 / 88

Location

United States

Related Subject Headings

  • Swine
  • Subarachnoid Hemorrhage
  • Severity of Illness Index
  • Rotation
  • Neurology & Neurosurgery
  • Motion
  • Hypoxia-Ischemia, Brain
  • Head Movements
  • Head Injuries, Closed
  • Disease Models, Animal
 

Citation

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Eucker, S. A., Smith, C., Ralston, J., Friess, S. H., & Margulies, S. S. (2011). Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol, 227(1), 79–88. https://doi.org/10.1016/j.expneurol.2010.09.015
Eucker, Stephanie A., Colin Smith, Jill Ralston, Stuart H. Friess, and Susan S. Margulies. “Physiological and histopathological responses following closed rotational head injury depend on direction of head motion.Exp Neurol 227, no. 1 (January 2011): 79–88. https://doi.org/10.1016/j.expneurol.2010.09.015.
Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS. Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011 Jan;227(1):79–88.
Eucker, Stephanie A., et al. “Physiological and histopathological responses following closed rotational head injury depend on direction of head motion.Exp Neurol, vol. 227, no. 1, Jan. 2011, pp. 79–88. Pubmed, doi:10.1016/j.expneurol.2010.09.015.
Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS. Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011 Jan;227(1):79–88.
Journal cover image

Published In

Exp Neurol

DOI

EISSN

1090-2430

Publication Date

January 2011

Volume

227

Issue

1

Start / End Page

79 / 88

Location

United States

Related Subject Headings

  • Swine
  • Subarachnoid Hemorrhage
  • Severity of Illness Index
  • Rotation
  • Neurology & Neurosurgery
  • Motion
  • Hypoxia-Ischemia, Brain
  • Head Movements
  • Head Injuries, Closed
  • Disease Models, Animal