Skip to main content
Journal cover image

Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury.

Publication ,  Journal Article
Friess, SH; Ralston, J; Eucker, SA; Helfaer, MA; Smith, C; Margulies, SS
Published in: Neurosurgery
November 2011

BACKGROUND: Small-animal models have been used in traumatic brain injury (TBI) research to investigate the basic mechanisms and pathology of TBI. Unfortunately, successful TBI investigations in small-animal models have not resulted in marked improvements in clinical outcomes of TBI patients. OBJECTIVE: To develop a clinically relevant immature large-animal model of pediatric neurocritical care following TBI. METHODS: Eleven 4-week-old piglets were randomly assigned to either rapid axial head rotation without impact (n = 6) or instrumented sham (n = 5). All animals had an intracranial pressure monitor, brain tissue oxygen tension (Pbto(2)) probe, and cerebral microdialysis probe placed in the frontal lobe and data collected for 6 hours following injury. RESULTS: Injured animals had sustained elevations in intracranial pressure and lactate-pyruvate ratio (LPR), and decreased Pbto(2) compared with sham. Pbto(2) and LPR from separate frontal lobes had strong linear correlation in both sham and injured animals. Neuropathologic examination demonstrated significant axonal injury and infarct volumes in injured animals compared with sham at 6 hours postinjury. Averaged over time, Pbto(2) in both injured and sham animals had a strong inverse correlation with total injury volume. Average LPR had a strong correlation with total injury volume. CONCLUSION: LPR and Pbto(2) can be utilized as serial nonterminal secondary markers in our injury model for neuropathology, and as evaluation metrics for novel interventions and therapeutics in the acute postinjury period. This translational model bridges a vital gap in knowledge between TBI studies in small-animal models and clinical trials in the pediatric TBI population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

November 2011

Volume

69

Issue

5

Start / End Page

1139 / 1147

Location

United States

Related Subject Headings

  • Swine
  • Pediatrics
  • Neurology & Neurosurgery
  • Monitoring, Physiologic
  • Microdialysis
  • Disease Models, Animal
  • Critical Care
  • Brain Injuries
  • Animals
  • Age Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friess, S. H., Ralston, J., Eucker, S. A., Helfaer, M. A., Smith, C., & Margulies, S. S. (2011). Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery, 69(5), 1139–1147. https://doi.org/10.1227/NEU.0b013e3182284aa1
Friess, Stuart H., Jill Ralston, Stephanie A. Eucker, Mark A. Helfaer, Colin Smith, and Susan S. Margulies. “Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury.Neurosurgery 69, no. 5 (November 2011): 1139–47. https://doi.org/10.1227/NEU.0b013e3182284aa1.
Friess SH, Ralston J, Eucker SA, Helfaer MA, Smith C, Margulies SS. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011 Nov;69(5):1139–47.
Friess, Stuart H., et al. “Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury.Neurosurgery, vol. 69, no. 5, Nov. 2011, pp. 1139–47. Pubmed, doi:10.1227/NEU.0b013e3182284aa1.
Friess SH, Ralston J, Eucker SA, Helfaer MA, Smith C, Margulies SS. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011 Nov;69(5):1139–1147.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

November 2011

Volume

69

Issue

5

Start / End Page

1139 / 1147

Location

United States

Related Subject Headings

  • Swine
  • Pediatrics
  • Neurology & Neurosurgery
  • Monitoring, Physiologic
  • Microdialysis
  • Disease Models, Animal
  • Critical Care
  • Brain Injuries
  • Animals
  • Age Factors