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Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury.

Publication ,  Journal Article
Zhou, C; Eucker, SA; Durduran, T; Yu, G; Ralston, J; Friess, SH; Ichord, RN; Margulies, SS; Yodh, AG
Published in: J Biomed Opt
2009

We used a nonimpact inertial rotational model of a closed head injury in neonatal piglets to simulate the conditions following traumatic brain injury in infants. Diffuse optical techniques, including diffuse reflectance spectroscopy and diffuse correlation spectroscopy (DCS), were used to measure cerebral blood oxygenation and blood flow continuously and noninvasively before injury and up to 6 h after the injury. The DCS measurements of relative cerebral blood flow were validated against the fluorescent microsphere method. A strong linear correlation was observed between the two techniques (R=0.89, p<0.00001). Injury-induced cerebral hemodynamic changes were quantified, and significant changes were found in oxy- and deoxy-hemoglobin concentrations, total hemoglobin concentration, blood oxygen saturation, and cerebral blood flow after the injury. The diffuse optical measurements were robust and also correlated well with recordings of vital physiological parameters over the 6-h monitoring period, such as mean arterial blood pressure, arterial oxygen saturation, and heart rate. Finally, the diffuse optical techniques demonstrated sensitivity to dynamic physiological events, such as apnea, cardiac arrest, and hypertonic saline infusion. In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit.

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Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2009

Volume

14

Issue

3

Start / End Page

034015

Location

United States

Related Subject Headings

  • Swine
  • Spectrum Analysis
  • Spectroscopy, Near-Infrared
  • Reproducibility of Results
  • Oxyhemoglobins
  • Oxygen
  • Oximetry
  • Optics and Photonics
  • Optics
  • Linear Models
 

Citation

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Zhou, C., Eucker, S. A., Durduran, T., Yu, G., Ralston, J., Friess, S. H., … Yodh, A. G. (2009). Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt, 14(3), 034015. https://doi.org/10.1117/1.3146814
Zhou, Chao, Stephanie A. Eucker, Turgut Durduran, Guoqiang Yu, Jill Ralston, Stuart H. Friess, Rebecca N. Ichord, Susan S. Margulies, and Arjun G. Yodh. “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury.J Biomed Opt 14, no. 3 (2009): 034015. https://doi.org/10.1117/1.3146814.
Zhou C, Eucker SA, Durduran T, Yu G, Ralston J, Friess SH, et al. Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt. 2009;14(3):034015.
Zhou, Chao, et al. “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury.J Biomed Opt, vol. 14, no. 3, 2009, p. 034015. Pubmed, doi:10.1117/1.3146814.
Zhou C, Eucker SA, Durduran T, Yu G, Ralston J, Friess SH, Ichord RN, Margulies SS, Yodh AG. Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt. 2009;14(3):034015.

Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2009

Volume

14

Issue

3

Start / End Page

034015

Location

United States

Related Subject Headings

  • Swine
  • Spectrum Analysis
  • Spectroscopy, Near-Infrared
  • Reproducibility of Results
  • Oxyhemoglobins
  • Oxygen
  • Oximetry
  • Optics and Photonics
  • Optics
  • Linear Models