Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila.

Published

Journal Article

Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pyd mutants, extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+ functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development.

Full Text

Duke Authors

Cited Authors

  • Chen, CM; Freedman, JA; Bettler, DR; Manning, SD; Giep, SN; Steiner, J; Ellis, HM

Published Date

  • July 1996

Published In

Volume / Issue

  • 57 / 2

Start / End Page

  • 215 - 227

PubMed ID

  • 8843398

Pubmed Central ID

  • 8843398

International Standard Serial Number (ISSN)

  • 0925-4773

Digital Object Identifier (DOI)

  • 10.1016/0925-4773(96)00548-5

Language

  • eng

Conference Location

  • Ireland