Explicit equilibrium modeling of transcription-factor binding and gene regulation.

Published

Journal Article

We have developed a computational model that predicts the probability of transcription factor binding to any site in the genome. GOMER (generalizable occupancy model of expression regulation) calculates binding probabilities on the basis of position weight matrices, and incorporates the effects of cooperativity and competition by explicit calculation of coupled binding equilibria. GOMER can be used to test hypotheses regarding gene regulation that build upon this physically principled prediction of protein-DNA binding.

Full Text

Duke Authors

Cited Authors

  • Granek, JA; Clarke, ND

Published Date

  • January 2005

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • R87 -

PubMed ID

  • 16207358

Pubmed Central ID

  • 16207358

Electronic International Standard Serial Number (EISSN)

  • 1474-760X

International Standard Serial Number (ISSN)

  • 1474-7596

Digital Object Identifier (DOI)

  • 10.1186/gb-2005-6-10-r87

Language

  • eng