Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.

Journal Article (Journal Article)

The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABA(A) IPSCs and a much slower and more sustained GABA(C) feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

Full Text

Duke Authors

Cited Authors

  • Vigh, J; Li, G-L; Hull, C; von Gersdorff, H

Published Date

  • May 5, 2005

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 469 - 482

PubMed ID

  • 15882646

Pubmed Central ID

  • PMC3572841

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2005.03.027


  • eng

Conference Location

  • United States