Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.
Journal Article (Journal Article)
The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABA(A) IPSCs and a much slower and more sustained GABA(C) feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.
Full Text
Duke Authors
Cited Authors
- Vigh, J; Li, G-L; Hull, C; von Gersdorff, H
Published Date
- May 5, 2005
Published In
Volume / Issue
- 46 / 3
Start / End Page
- 469 - 482
PubMed ID
- 15882646
Pubmed Central ID
- 15882646
International Standard Serial Number (ISSN)
- 0896-6273
Digital Object Identifier (DOI)
- 10.1016/j.neuron.2005.03.027
Language
- eng
Conference Location
- United States