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Autophagy and tumor cell dormancy in head and neck cancer

Publication ,  Conference
Jang, DW; Avivar-Valderas, A; Banach, A; Aguirre-Ghiso, J
Published in: Laryngoscope
January 1, 2011

Educational Objective: At the conclusion of this presentation, the participants should be able to discuss the concepts of autophagy and tumor cell dormancy, and how these cellular processes may be targeted in order to prolong survival in patients with squamous cell carcinoma of the head and neck. Objective: (1) To explain the concept of tumor cell dormancy (2) To define the role of autophagy, which is a form of nutrient recycling, as a mechanism by which dormant tumor cells survive nutrient deprivation 3) To identify a molecular pathway responsible for the induction of autophagy. Study Design / Methods: In vivo laboratory study using the HEp3 cell line. Results: Dormant HEp3 (DHEp3) cells had a significantly higher baseline level of autophagy as compared to tumorigenic HEp3 (THEp3) cells. DHEp3 cells also had higher viability rates after treatment with chloroquine. Activation of pERK in THEp3 cells increased autophagy, while deactivation of pERK in DHEp3 cells decreased autophagy. Conclusion: Pharmacological inhibition of autophagy or the pERK pathway may prolong survival in patients with locally advanced head and neck cancer.

Duke Scholars

Published In

Laryngoscope

DOI

EISSN

1531-4995

ISSN

0023-852X

Publication Date

January 1, 2011

Volume

121

Issue

SUPPL. 4

Start / End Page

S125

Related Subject Headings

  • Otorhinolaryngology
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
MLA
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Jang, D. W., Avivar-Valderas, A., Banach, A., & Aguirre-Ghiso, J. (2011). Autophagy and tumor cell dormancy in head and neck cancer. In Laryngoscope (Vol. 121, p. S125). https://doi.org/10.1002/lary.22002
Jang, D. W., A. Avivar-Valderas, A. Banach, and J. Aguirre-Ghiso. “Autophagy and tumor cell dormancy in head and neck cancer.” In Laryngoscope, 121:S125, 2011. https://doi.org/10.1002/lary.22002.
Jang DW, Avivar-Valderas A, Banach A, Aguirre-Ghiso J. Autophagy and tumor cell dormancy in head and neck cancer. In: Laryngoscope. 2011. p. S125.
Jang, D. W., et al. “Autophagy and tumor cell dormancy in head and neck cancer.” Laryngoscope, vol. 121, no. SUPPL. 4, 2011, p. S125. Scopus, doi:10.1002/lary.22002.
Jang DW, Avivar-Valderas A, Banach A, Aguirre-Ghiso J. Autophagy and tumor cell dormancy in head and neck cancer. Laryngoscope. 2011. p. S125.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

ISSN

0023-852X

Publication Date

January 1, 2011

Volume

121

Issue

SUPPL. 4

Start / End Page

S125

Related Subject Headings

  • Otorhinolaryngology
  • 1103 Clinical Sciences