Prohemostatic treatment in cardiac surgery.

Other Article (Journal Article;Review)

Cardiac surgical patients represent a unique group of patients where coagulopathy occurs due to multiple causes besides simple hemorrhagic blood loss. Hemodilution, inflammation, and hemostatic activation while on cardiopulmonary bypass all contribute to this problem and provide targets for therapeutic intervention. Current pharmacological strategies to reduce the need for allogeneic transfusions include both preemptive agents to decrease the potential for bleeding as well as prohemostatic agents to promote the coagulation process. This article will discuss pharmacological agents including antifibrinolytics, protamine, desmopressin, fibrinogen, purified protein concentrates, recombinant factor VIIa, factor XIII, and topical agents used in cardiac surgery.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Sniecinski, RM

Published Date

  • April 2012

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 237 - 243

PubMed ID

  • 22510857

Electronic International Standard Serial Number (EISSN)

  • 1098-9064

Digital Object Identifier (DOI)

  • 10.1055/s-0032-1304223


  • eng

Conference Location

  • United States