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Novel oral anticoagulants: implications in the perioperative setting.

Publication ,  Other
Levy, JH; Key, NS; Azran, MS
Published in: Anesthesiology
September 2010

Patients undergoing surgery receive anticoagulation for perioperative thromboprophylaxis or ischemic cardiovascular disease. Because anticoagulants may also potentiate bleeding, clinicians need to understand the implications of anticoagulation in perioperative and postoperative patient management. Many newer anticoagulants that are now available or are in clinical development do not require routine coagulation monitoring, have more predictable dose responses, and have fewer interactions with other drugs and food. The most advanced oral anticoagulants in clinical development are the direct factor Xa inhibitors rivaroxaban and apixaban, and the direct thrombin inhibitor dabigatran etexilate. These agents have been evaluated in the postoperative setting in patients undergoing total hip- or knee-replacement surgery with promising results, and it remains to be seen whether these results will translate into other surgical settings. The impact of the new agents will be influenced by the balance between efficacy and safety, improved convenience, and potential cost-effectiveness benefits.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

September 2010

Volume

113

Issue

3

Start / End Page

726 / 745

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Perioperative Care
  • Humans
  • Blood Coagulation
  • Arthroplasty, Replacement, Knee
  • Anticoagulants
  • Animals
  • Anesthesiology
  • Administration, Oral
  • 3202 Clinical sciences
 

Citation

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Levy, J. H., Key, N. S., & Azran, M. S. (2010). Novel oral anticoagulants: implications in the perioperative setting. Anesthesiology. United States. https://doi.org/10.1097/ALN.0b013e3181ebdb15
Levy, Jerrold H., Nigel S. Key, and Marc S. Azran. “Novel oral anticoagulants: implications in the perioperative setting.Anesthesiology, September 2010. https://doi.org/10.1097/ALN.0b013e3181ebdb15.
Levy JH, Key NS, Azran MS. Novel oral anticoagulants: implications in the perioperative setting. Vol. 113, Anesthesiology. 2010. p. 726–45.
Levy, Jerrold H., et al. “Novel oral anticoagulants: implications in the perioperative setting.Anesthesiology, vol. 113, no. 3, Sept. 2010, pp. 726–45. Pubmed, doi:10.1097/ALN.0b013e3181ebdb15.
Levy JH, Key NS, Azran MS. Novel oral anticoagulants: implications in the perioperative setting. Anesthesiology. 2010. p. 726–745.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

September 2010

Volume

113

Issue

3

Start / End Page

726 / 745

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • Perioperative Care
  • Humans
  • Blood Coagulation
  • Arthroplasty, Replacement, Knee
  • Anticoagulants
  • Animals
  • Anesthesiology
  • Administration, Oral
  • 3202 Clinical sciences