Management of surgical hemostasis: systemic agents.

Journal Article (Journal Article;Review)

Despite improvements in surgical techniques, the risk for perioperative bleeding remains significant. Transfusion of allogeneic red blood cells, platelets, and hemostatic factors remains the mainstay of current therapy strategy for management of perioperative bleeding. Transfusions significantly contribute to perioperative adverse events. Pharmacologic strategies to prevent or decrease perioperative bleeding are also important therapeutic approaches to reduce the need for allogeneic transfusions. This article discusses systemic pharmacologic prohemostatic agents (aprotinin, lysine analogues, protamine, desmopressin, and recombinant factor VIIa).

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Tanaka, KA

Published Date

  • 2008

Published In

Volume / Issue

  • 16 Suppl 1 /

Start / End Page

  • S14 - S21

PubMed ID

  • 18544301

International Standard Serial Number (ISSN)

  • 1708-5381


  • eng

Conference Location

  • England