Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa.

Journal Article (Journal Article)

BACKGROUND: Changes in the Jehovah's Witness (JW) blood refusal policy now give members the personal choice to accept certain processed fractions of blood, such as factor concentrates and cryoprecipitate. METHODS: Two JW patients undergoing complex aortic surgery who developed severe microvascular bleeding after prolonged use of cardiopulmonary bypass were treated with recombinant activated factor VII, cryoprecipitate, and antithrombin concentrate. RESULTS: Cardiopulmonary bypass-induced coagulopathy was successfully treated, allowing chest closure without evidence of thrombotic complications. CONCLUSIONS: Processed blood fractions can be a valuable adjuvant to drugs when treating bleeding in JW patients.

Full Text

Duke Authors

Cited Authors

  • Sniecinski, RM; Chen, EP; Levy, JH; Szlam, F; Tanaka, KA

Published Date

  • April 2007

Published In

Volume / Issue

  • 104 / 4

Start / End Page

  • 763 - 765

PubMed ID

  • 17377078

Electronic International Standard Serial Number (EISSN)

  • 1526-7598

Digital Object Identifier (DOI)

  • 10.1213/01.ane.0000250913.45299.f3


  • eng

Conference Location

  • United States