Intravenous milrinone in cardiac surgery.

Other Article (Journal Article;Review)

Phosphodiesterase inhibitors including milrinone produce positive inotropic effects by slowing the hydrolysis of cyclic adenosine monophosphate in the myocardium. With a loading dose of 50 microg/kg followed by an infusion of 0.5 microg x kg(-1) x min(-1), milrinone increases stroke volume index and left ventricular velocity of circumferential fiber shortening after weaning from cardiopulmonary bypass. Milrinone has potential for the treatment and prevention of internal mammary artery spasm because of its vasodilative effect, which is similar to that of papaverine, and is a potent pulmonary vasodilator for patients with right ventricular dysfunction and pulmonary vasoconstriction. Low-dose milrinone may have antiinflammatory properties and potentially can improve splanchnic perfusion.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Bailey, JM; Deeb, GM

Published Date

  • January 2002

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 325 - 330

PubMed ID

  • 11834047

International Standard Serial Number (ISSN)

  • 0003-4975

Digital Object Identifier (DOI)

  • 10.1016/s0003-4975(01)02719-9


  • eng

Conference Location

  • Netherlands