Amrinone: its effect on vascular resistance and capacitance in human subjects.

Published

Journal Article

Reports evaluating amrinone's effects in normal (intact) human subjects are complex and difficult to interpret because of the drug's diverse effects on myocardial function, resistance vessels, and vascular capacitance. In this study, 1.5 mg/kg of amrinone was administered as an intravenous bolus to cardiac surgical patients during constant flow cardiopulmonary bypass to determine its isolated effects on venous capacitance and vascular resistance. We noted a significant decrease in vascular resistance up to 8 min after injection and a 460 +/- 160 ml (mean +/- SD) decrease in venous reservoir volume 10 min after injection. Amrinone has potent venous and arterial vasodilating properties that make it a unique drug for treating congestive heart failure in addition to its reported positive inotropic effects.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Bailey, JM

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 105 / 1

Start / End Page

  • 62 - 64

PubMed ID

  • 8275786

Pubmed Central ID

  • 8275786

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.105.1.62

Language

  • eng

Conference Location

  • United States