Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine
Publication
, Journal Article
Levy, JH; Adelson, D
Published in: Agents and Actions
June 1, 1992
All muscle relaxants inhibit histamine N-methyltransferase in vitro, but vecuronium, a steroid-derived muscle relaxant, is the most potent inhibitor. It has been suggested that administration of vecuronium prior to giving a drug that releases histamine may exaggerate the hemodynamic or vascular effects. Volunteers were injected intradermally with 5×10-4M concentrations of histamine, and the combination of vecuronium and histamine, to evaluate the in vivo significance. Vecuronium did not alter the measured wheal and flare responses to injected histamine at 5, 15, 30, 40, 50 and 60 mins. There is no evidence that inhibition of histamine N-methyltransferase in vivo will alter the vascular effects of histamine. © 1992 Birkhäuser Verlag.
Duke Scholars
Published In
Agents and Actions
DOI
EISSN
1420-908X
ISSN
0065-4299
Publication Date
June 1, 1992
Volume
36
Issue
2 Supplement
Citation
APA
Chicago
ICMJE
MLA
NLM
Levy, J. H., & Adelson, D. (1992). Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine. Agents and Actions, 36(2 Supplement). https://doi.org/10.1007/BF01997336
Levy, J. H., and D. Adelson. “Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine.” Agents and Actions 36, no. 2 Supplement (June 1, 1992). https://doi.org/10.1007/BF01997336.
Levy JH, Adelson D. Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine. Agents and Actions. 1992 Jun 1;36(2 Supplement).
Levy, J. H., and D. Adelson. “Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine.” Agents and Actions, vol. 36, no. 2 Supplement, June 1992. Scopus, doi:10.1007/BF01997336.
Levy JH, Adelson D. Effects of vecuronium-induced histamine N-methyltransferase inhibition on cutaneous responses to histamine. Agents and Actions. 1992 Jun 1;36(2 Supplement).
Published In
Agents and Actions
DOI
EISSN
1420-908X
ISSN
0065-4299
Publication Date
June 1, 1992
Volume
36
Issue
2 Supplement