Effects of protamine on histamine release from human lung.

Journal Article (Journal Article)

Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparin-protamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for protamine reactions in man.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Faraj, BA; Zaidan, JR; Camp, VM

Published Date

  • August 1, 1989

Published In

Volume / Issue

  • 28 / 1-2

Start / End Page

  • 70 - 72

PubMed ID

  • 2476923

International Standard Serial Number (ISSN)

  • 0065-4299

Digital Object Identifier (DOI)

  • 10.1007/BF02022982


  • eng

Conference Location

  • Switzerland