Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.

Published

Journal Article

Rods and cones are morphologically and developmentally distinct photoreceptor types with different functions in vision. Cones mediate daylight and color vision and in most mammals express M and S opsin photopigments for sensitivity to medium-long and short light wavelengths, respectively. Rods mediate dim light vision and express rhodopsin photopigment. The transcription factor networks that direct differentiation of each photoreceptor type are incompletely defined. Here, we report that Rorb(-/-) mice lacking retinoid-related orphan nuclear receptor beta lose rods but overproduce primitive S cones that lack outer segments. The phenotype reflects pronounced plasticity between rod and cone lineages and resembles that described for Nrl(-/-) mice lacking neural retina leucine zipper factor. Rorb(-/-) mice lack Nrl expression and reexpression of Nrl in Rorb(-/-) mice converts cones to rod-like cells. Thus, Rorb directs rod development and does so at least in part by inducing the Nrl-mediated pathway of rod differentiation.

Full Text

Cited Authors

  • Jia, L; Oh, ECT; Ng, L; Srinivas, M; Brooks, M; Swaroop, A; Forrest, D

Published Date

  • October 2009

Published In

Volume / Issue

  • 106 / 41

Start / End Page

  • 17534 - 17539

PubMed ID

  • 19805139

Pubmed Central ID

  • 19805139

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0902425106

Language

  • eng