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A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease.

Publication ,  Journal Article
Zhang, X; Hyjek, E; Vardiman, J
Published in: Am J Clin Pathol
May 2013

In this study we investigated the distribution of IgG4+ plasma cells and regulatory T (T(REG)) cells, a major regulator of IgG4 production, in nodal and extranodal Rosai-Dorfman disease (RDD). Twenty-six specimens (15 nodal, 11 extranodal) were examined, with reactive lymph nodes and site-matched extranodal specimens as controls. Overall, 84.6% (22/26) of the specimens showed various degrees of sclerosis (7 mild, 8 moderate, and 7 severe). Nineteen cases (73.1%) exhibited more than 10 IgG4+ cells/0.060 mm(2) (photographed area at ×40), and 8 cases (30.8%) showed more than 40% of IgG+ cells being IgG4+. Only 1 control case exhibited more than 10 IgG4+ cells/0.060 mm(2) (P < .05). The number of T(REG) cells was comparable between nodal RDD and controls, whereas extranodal RDD exhibited significantly higher numbers of T(REG) cells than controls. These findings demonstrate that a subset of RDD shows features of IgG4-related disease and indicate an overlap between certain aspects of the 2 diseases.

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Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

May 2013

Volume

139

Issue

5

Start / End Page

622 / 632

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Sclerosis
  • Plasma Cells
  • Pathology
  • Middle Aged
  • Male
  • Lymphatic Diseases
  • Lymph Nodes
  • Infant
  • Immunoglobulin G
 

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Zhang, X., Hyjek, E., & Vardiman, J. (2013). A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease. Am J Clin Pathol, 139(5), 622–632. https://doi.org/10.1309/AJCPARC3YQ0KLIOA
Zhang, Xuefeng, Elizabeth Hyjek, and James Vardiman. “A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease.Am J Clin Pathol 139, no. 5 (May 2013): 622–32. https://doi.org/10.1309/AJCPARC3YQ0KLIOA.
Zhang X, Hyjek E, Vardiman J. A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease. Am J Clin Pathol. 2013 May;139(5):622–32.
Zhang, Xuefeng, et al. “A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease.Am J Clin Pathol, vol. 139, no. 5, May 2013, pp. 622–32. Pubmed, doi:10.1309/AJCPARC3YQ0KLIOA.
Zhang X, Hyjek E, Vardiman J. A subset of Rosai-Dorfman disease exhibits features of IgG4-related disease. Am J Clin Pathol. 2013 May;139(5):622–632.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

May 2013

Volume

139

Issue

5

Start / End Page

622 / 632

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Sclerosis
  • Plasma Cells
  • Pathology
  • Middle Aged
  • Male
  • Lymphatic Diseases
  • Lymph Nodes
  • Infant
  • Immunoglobulin G