The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth.


Journal Article

We investigated truncated glioma-associated oncogene homolog 1 (TGLI1) that behaves as gain-of-function GLI1 and promotes tumor cell migration and invasion. Herein, we report that TGLI1 had a higher propensity than GLI1 to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro. TGLI1 has gained the ability to enhance expression of pro-angiogenic heparanase. In patient glioblastomas, TGLI1 levels are correlated with heparanase expression. Together, we report that TGLI1 is a novel mediator of glioblastoma angiogenesis and that heparanase is a novel transcriptional target of TGLI1, shedding new light on the molecular pathways that support tumor angiogenesis and aggressive growth.

Full Text

Cited Authors

  • Zhu, H; Carpenter, RL; Han, W; Lo, H-W

Published Date

  • February 1, 2014

Published In

Volume / Issue

  • 343 / 1

Start / End Page

  • 51 - 61

PubMed ID

  • 24045042

Pubmed Central ID

  • 24045042

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2013.09.014


  • eng

Conference Location

  • Ireland