Pharmacoeconomics of hematopoietic stem cell mobilization: an overview of current evidence and gaps in the literature.

Journal Article (Journal Article;Review)

Adequate hematopoietic stem cell (HSC) mobilization and collection is required prior to proceeding with high dose chemotherapy and autologous hematopoietic stem cell transplant. Cytokines such as G-CSF, GM-CSF, and peg-filgrastim, alone or in combination with plerixafor, and after chemotherapy have been used to mobilize HSCs. Studies have shown that the efficiency of HSC mobilization and collection may vary when different methods of mobilization are used. No studies have shown that survival is significantly affected by the method of mobilization, but some studies have suggested that cost and resource utilization may be different between different mobilization techniques. After the FDA approval of plerixafor with G-CSF to mobilize HSCs many transplant centers became concerned about the cost of HSC mobilization. A panel of experts was convened ant this paper reviews the current literature on the pharmacoeconomics of HSC mobilization.

Full Text

Duke Authors

Cited Authors

  • Shaughnessy, P; Chao, N; Shapiro, J; Walters, K; McCarty, J; Abhyankar, S; Shayani, S; Helmons, P; Leather, H; Pazzalia, A; Pickard, S

Published Date

  • September 2013

Published In

Volume / Issue

  • 19 / 9

Start / End Page

  • 1301 - 1309

PubMed ID

  • 23685251

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2013.05.008


  • eng

Conference Location

  • United States