Myometrial hyperplasia mimics the clinical presentation of uterine fibroids: a report of 3 cases.

Journal Article (Journal Article)

The clinical diagnosis of fibroid uterus is based on physical examination findings and/or ultrasound. However, it is not uncommon for routine pathology examination to report no significant fibroids in such cases. Myometrial hyperplasia (MMH) is a structural variation with irregular zones of hypercellularity and increased nucleus/cell ratio that appears in adolescence, can progress during the childbearing years, and can sometimes cause grossly detectable bulges on pathologic examination. MMH can be inframucosal, intramural (microscopic), or subserosal. Three premenopausal women with a preoperative diagnosis of fibroids on pelvic examination, and/or sonograms, underwent hysterectomies. In all the 3 cases, the Myoma Index (number of fibroids×size of largest fibroid) indicated insignificant fibroids. The pathology simulating fibroids was firm, bulging inframucosal MMH. Firm, bulging MMH can mimic uterine fibroids on ultrasound and physical examination. In hysterectomies for fibroid uterus with a Myoma Index <3.7, it is recommended that pathologists evaluate for MMH as the possible explanation for the findings on physical examination and/or ultrasound.

Full Text

Duke Authors

Cited Authors

  • Newcomb, PM; Cramer, SF; Leppert, PC

Published Date

  • November 2013

Published In

Volume / Issue

  • 32 / 6

Start / End Page

  • 585 - 591

PubMed ID

  • 24071875

Electronic International Standard Serial Number (EISSN)

  • 1538-7151

Digital Object Identifier (DOI)

  • 10.1097/PGP.0b013e31827630d4


  • eng

Conference Location

  • United States